Mannose binding lectin- genetic variations, deficiency and disease associations
نویسندگان
چکیده
منابع مشابه
Disease associations of mannose-binding lectin & potential of replacement therapy.
Mannose-binding lectin (MBL) is an important component of the immune defence able to bind to repeating mannose based structural patterns typical of microbial surface (bacteria, viruses, fungi, parasites) leading to opsonization and phagocytosis, and activation of the complement pathway resulting in lysis of the pathogen. MBL thus plays a very important role in the first line of host immune resp...
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One of the important parts of innate immunity is complement system that occurs in three different ways; the classic, the alternative and the lectin pathway. The four pattern recognition molecules that have been identified till now are Mannose binding lectin (MBL), a component of lectin pathway, and three ficolins (ficolin1,-2 and -3) which compound to the carbohydrates of the cell surface. MBL ...
متن کاملMannose-binding lectin deficiency and respiratory tract infection.
Mannose-binding lectin (MBL) is an innate immune system pattern recognition protein that kills a wide range of pathogenic microbes through complement activation. A substantial proportion of all human populations studied to date have MBL deficiency due to MBL2 polymorphisms, which potentially increases susceptibility to infectious disease. MBL binds numerous respiratory pathogens but the capsule...
متن کاملMannose Binding Lectin Deficiency: More than Meets the Eye
This case report describes a 5-year-old boy who presented to the emergency department with clinical symptoms and chest X-ray findings suggestive of pneumonia. Further history revealed multiple other infections, and workup for immunodeficiency revealed a deficiency of mannose-binding lectin (MBL), a pattern recognition receptor involved in activation of the complement system. Innate immunodefici...
متن کاملinvestigation of mannose–binding lectin level and deficiency in patients with dermatophytosis
background dermatophytosis is a cutaneous fungal infection with a worldwide occurrence. in dermatophyte infections, the release of keratinocyte cytokines, in the presence of dermatophyte antigens, causes an acute phase response; subsequently, the acute-phase proteins are produced by hepatocytes. mannose–binding lectin (mbl), an acute-phase protein, also acts as a kind of pattern recognition rec...
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ژورنال
عنوان ژورنال: Annals of SBV
سال: 2016
ISSN: 2395-1982
DOI: 10.5005/jp-journals-10085-5114